Gynecomastia in adolescents

Authors

  • Rok Kralj Klinika za dječje bolesti Zagreb
  • Mario Kurtanjek Children's Hospital Zagreb
  • Fran Matijević Children's Hospital Zagreb
  • Anita Špehar Uroić Children's Hospital Zagreb
  • Stjepan Višnjić Children's Hospital Zagreb

DOI:

https://doi.org/10.13112/pc.1116

Keywords:

Gynecomastia; Adolescent; Therapeutics

Abstract

Gynecomastia is a benign enlargement of male breasts due to the proliferation of glandular tissue. In adolescents, pubertal gynecomastia is the most common, and it probably occurs as a result of a transient hormonal imbalance between androgens and estrogens. Less commonly, some pathological conditions may also be the cause. Diagnostic work-up includes medical history, clinical examination, laboratory tests, and imaging. Treatment is typically unnecessary, as spontaneous remission occurs in up to 90 % of cases. If gynecomastia persists, drug and surgical therapy are considered. Selective estrogen receptor modulators are the first line of drug therapy. Surgical treatment is considered if spontaneous remission has not occurred two years after the onset of gynecomastia. The authors suggest subcutaneous mastectomy according to Webster for milder forms, and mastectomy with removal of excess skin and free nipple graft for more severe forms of gynecomastia.

Author Biographies

  • Mario Kurtanjek, Children's Hospital Zagreb

    Pediatric Surgery Department

  • Fran Matijević, Children's Hospital Zagreb

    Department of Pediatric Surgery

  • Anita Špehar Uroić, Children's Hospital Zagreb

    Department of Pediatrics

  • Stjepan Višnjić, Children's Hospital Zagreb

    Department of Pediatric Surgery

    Head

References

1. Moon JE, Ko CW, Yang JD, Lee JS. Combined surgical and medical treatment in an adolescent with severe gynecomastia due to excessive estradiol secretion : a case report. BMC Pediatrics 2019;19:515-20.

2. Braunstein GD. Gynecomastia. N Engl J Med 1993;328(7):490–5.

3. Philip K, Fnu D, Ralitsa R, Analia T, Jianbo L Ashok. A relationship of adolescent gynecomastia with varicocele and somatometric parameters: a cross-sectional study in 6200 healthy boys. J Adolesc Health. 2007;41:126–31.

4. Limony Y, Friger M, Hochberg Z. Pubertal gynecomastia coincides with peak height velocity. J Clin Res Pediatr Endocrinol 2013;5:142.

5. Nydick M, Bustos J, Dale JH, Rawson RW. Gynecomastia inadolescent boys. JAMA 1961;178: 449–54.

6. Biro FM, Lucky AW, Huster GA, Morrison JA. Hormonal studies and physical maturation in adolescent gynecomastia. J Pediatr 1990;116: 450–5.

7. Moore DC, Schlaepfer LV, Paunier L, Sizonenko PC. Hormonalchanges during puberty: V. transient pubertal gynecomastia: abnormal androgen-estrogen ratios. J Clin Endocrinol Metab 1984;58:49

8. Braunstein GD. Gynecomastia. N Engl J Med 2007; 357:1229–37.

9. Lee KO, Chua DY, Cheah JS. Oestrogen and progesterone receptors in men with bilateral or unilateral pubertal macromastia. Clin Endocrinol (Oxf) 1990;32: 101–5.

10. Priskorn L, Nordkap L, Bang AK, Krause M, Holmboe SA, Egeberg Palme DL i sur. Average sperm count remains unchanged despite reduction in maternal smoking: results from a large cross-sectional study with annual investigations over 21 years. Hum Reprod 2018;33:998–1008.

11. Kanakis GA, Nordkap L, Bang AK, Calogero AE, Bartfai G, Corona G i sur. EAA clinical practice guidelines – gynecomastia evaluation and management. Andrology 2019;7:778-93.

12. Soliman AT, De Sanctis V, Yassin M. Management of adolescent gynecomastia: an update. Acta Biomed 2017;88(2):204-13.

13. Simon BE, Hoffman S, Kahn S. Classification and surgical correction of gynecomastia. Plast Recon Surg 1973;51:48-52.

14. Ma NS, Geffner ME. Gynecomastia in prepubertal and pubertal men. Curr Opin Pediatr 2008;20(4):465-70.

15. Torio-Padron N. Gynäkomastie. U :Schiestl C, Stark GB, Lenz Y, Neuhaus K ur. Plastische Chirurgie bei Kindern und Jugendlichen. Berlin: Springer; 2017:491-6.

16. Taylor SA. Gynecomastia in children and adolescents. In: Connor R, ur. UpToDate. Wolters Kluwer; 2024. [pristupljeno 22.08.2025.]

17. Fischer S, Hirsch T, Hirche C, Kiefer J, Kueckelhaus M, Germann G i sur.. Surgical treatment of primary gynecomatia in children and adolescents. Pediatr Surg Int 2014;30(6):641-7. doi: 10.1007/s00383-014-3508-8.

18. Patel P, Tibb FJ. Tamoxifen. National Library of Medicine web stranica.2025 [Pristupljeno 10.5.2025]. Dostupno na: Tamoxifen - StatPearls - NCBI Bookshelf

19. Derman O, Kanbur N, Kilic I, Kutluk T. Long-term follow-up of tamoxifen treatment in adolescents with gynecomastia. J Pediatr Endocrinol Metab 2008;21(5):449–54.

20. Devoto CE, Madariaga AM, Lioi C X, Mardones N. Influence of size and duration of gynecomastia on its response to treatment with tamoxifen. Rev Med Chil 2007; 135: 1558-1565.

21. Akgül S, Kanbur N, Güçer Ş, Şafak T, Derman O. The histopathological effects of tamoxifen in the treatment of pubertal gynecomastia. J Pediatr Endocrinol Metab 2012;25:753-5.

22. Metwalley KA, Farghaly HS. Gynecomastia in adolescent males: current understanding of its etiology, pathophysiology, diagnosis, and treatment. Ann Pediatr Endocrinol Metab 2024;29(2):75-81.

23. Pinelli M, De Maria F, Ceccarelli P, Bianchini MA, Pedrieri B, Iughetti L i sur.. Surgical management of adolescents with severe gynecomastia: Personal experience and outcome analysis. Acta Biomed 2023;94:2:e2023055

24. Narula HS, Carlson HE. Gynaecomastia—pathophysiology, diagnosis and treatment. Nat Rev Endocrinol. 2014;10(11):684-98. doi:10.1038/nrendo.2014.139

25. Webster JP. Mastectomy for gynecomastia through a semicircular intra-areolar incision. Ann Surg 1946;124(3):557–75.

26. Aiache AE. Male chest correction. pectoral implants and gynecomastia. Clin Plast Surg 1991;18(4):823–8.

27. Laituri CA, Garey CL, Ostlie DJ, St. Peter SD, Gittes GK, Snyder CL. Treatment of adolescent gynecomastia. J Ped Surg 2010;45:650-4.

28. Belza CC, Blum JD, Neubauer D, Reid CM, Ortiz-Pomales YT, Lance SH. A Rretrospective review of arthroscopic shaver utilization in adolescent gynecomastia. PRS Glob Open 2023;11(10):e5336.

29. Nuzzi LC, Firriolo JM, Pike CM, Cerrato FE, DiVasta AD, Labow BI. The effect of surgical treatment for gynecomastia on quality of life in adolescents. J Adolesc Health 2018;63:759-65.

30. Lashin R, Youseff RA, Elshahat A, Mohamed EN. Postoperative psychological impact on teenagers after gynecomastia correction. Plast Reconstr Surg Glob Open 2023; 11(6):e5094

31. Ordaz DL, Thompson JK. Gynecomastia and psychological functioning: a review of the literature. Body Image 205;15:141–8.

32. Rew L, Young C, Harrison T,Caridi R. A systematic review ofliterature on psychosocial aspects of gynecomastia in adolescents and young men. J Adolesc 2015;43:206–12.

33. Arora Y, Mittal RR, Williams EA, Thaller SR. Barriers to the Effective Management of Gynecomastia in Adolescents. J Craniofac Surg. 2019;30(8):2381-4.

Published

2026-03-30

Issue

Section

Review

How to Cite

Kralj, R., Kurtanjek, M., Matijević, F., Špehar Uroić, A., & Višnjić, S. (2026). Gynecomastia in adolescents. Paediatria Croatica, 70(1), 26-31. https://doi.org/10.13112/pc.1116

Similar Articles

1-10 of 107

You may also start an advanced similarity search for this article.

Most read articles by the same author(s)

1 2 > >>