Systematic neuromonitoring – our treatment program for premature infants

Authors

  • Tomislav Ćaleta Medicinski fakultet Sveučilišta u Zagrebu Zavod za neonatologiju i neonatalnu intenzivnu medicinu Klinika za pedijatriju KBC Zagreb

DOI:

https://doi.org/10.13112/pc.1206

Keywords:

Infant, Premature; Ultrasonography; Magnetic Resonance Imaging; Spectroscopy, Near-Infrared

Abstract

Preterm birth remains a major global health challenge and is associated with significant long-term neurodevelopmental morbidity. Modern neonatal care increasingly relies on an integrated neuromonitoring approach that combines structural and functional assessment of the preterm brain. Serial cranial ultrasound represents the cornerstone of bedside monitoring due to its availability, safety, and ability to detect intraventricular hemorrhage and cystic white matter injury. However, magnetic resonance imaging provides superior sensitivity for detecting non-cystic white matter lesions and subtle structural abnormalities, allowing more accurate prognostic evaluation. Near-infrared spectroscopy (NIRS) adds a functional dimension by enabling continuous monitoring of regional cerebral oxygen saturation and autoregulatory stability, particularly during the first days of life when the risk of brain injury is highest. The integration of clinical assessment with multimodal neuromonitoring facilitates early identification of high-risk infants and supports timely therapeutic interventions aimed at optimizing hemodynamics, ventilation, and oxygenation. Such a systematic and comprehensive strategy has the potential to improve long-term neurodevelopmental outcomes in preterm infants.

References

1. Perin J, Mulick A, Yeung D, Villavicencio F, Lopez G, Strong KL, et al. Global, regional, and national causes of under-5 mortality in 2000–19: an updated systematic analysis with implications for the sustainable development goals. Lancet Child Adolesc Health. 2022;6:106-15.

2. Pascal A, Govaert P, Oostra A, Naulaers G, Ortibus E, Van den Broeck C. Neurodevelopmental outcome in very preterm and very-low-birthweight infants born over the past decade: a meta-analytic review. Dev Med Child Neurol. 2018;60:342-55.

3. Hrvatski zavod za javno zdravstvo. Hrvatski zdravstveno-statistički ljetopis za 2023. godinu [Internet]. Zagreb: Hrvatski zavod za javno zdravstvo; 2024 [pristupljeno 19. 01. 2026.]. Dostupno na: https://www.hzjz.hr/hrvatski-zdravstveno-statisticki-ljetopis/hrvatski-zdravstveno-statisticki-ljetopis-za-2023-g-tablicni-podaci/

4. Cuzzilla R, Spittle AJ, Lee KJ, Rogerson S, Cowan FM, Doyle LW, et al. Postnatal brain growth assessed by sequential cranial ultrasonography in infants born <30 weeks’ gestational age. AJNR Am J Neuroradiol. 2018;39:1170-6.

5. Al-Abdi S, Al-Aamri M. A systematic review and meta-analysis of the timing of early intraventricular hemorrhage in preterm neonates: clinical and research implications. J Clin Neonatol. 2014;3:76-80.

6. Steggerda SJ, Leijser LM, Wiggers-de Bruïne FT, van der Grond J, Walther FJ, van Wezel-Meijler G. Cerebellar injury in preterm infants: incidence and findings on US and MR images. Radiology. 2009;252:190-9.

7. Inder TE, Anderson NJ, Spencer C, Wells SJ, Volpe JJ. White matter injury in the premature infant: a comparison between serial cranial sonographic and MR findings at term. AJNR Am J Neuroradiol. 2003;24:805-9.

8. Inder TE, Wells SJ, Mogridge NB, Spencer C, Volpe JJ. Defining the nature of the cerebral abnormalities in the premature infant: a qualitative magnetic resonance imaging study. J Pediatr. 2003;143:171-9.

9. Guo T, Duerden EG, Adams E, Chau V, Branson HM, Chakravarty MM, et al. Quantitative assessment of white matter injury in preterm neonates. Neurology. 2017;88:614-22.

10. Inder TE, de Vries LS, Ferriero DM, Grant PE, Ment LR, Miller SP, et al. Neuroimaging of the preterm brain: review and recommendations. J Pediatr. 2021;237:276-87.

11. Greisen G, Leung T, Wolf M. Has the time come to use near-infrared spectroscopy as a routine clinical tool in preterm infants undergoing intensive care? Philos Trans A Math Phys Eng Sci. 2011;369:4440-51.

12. Alderliesten T, Dix L, Baerts W, Caicedo A, Van Huffel S, Naulaers G, et al. Reference values of regional cerebral oxygen saturation during the first 3 days of life in preterm neonates. Pediatr Res. 2016;79:55-64.

13. Grizelj R, Ryll MJ, Bojanić K, Ćaleta T, Sindičić Dessardo N, Vukšić I, et al. Regional cerebral oxygen saturation reference values in extremely and very preterm neonates using neonatal sensors: a prospective observational cohort study. BMJ Paediatr Open. 2025;9:e003239.

14. Ćaleta T, Ryll MJ, Bojanić K, Dessardo NS, Schroeder DR, Sprung J, et al. Regional cerebral oxygen saturation variability and brain injury in preterm infants. Front Pediatr. 2024;12:1426874.

Published

2026-04-03

How to Cite

Ćaleta, T. (2026). Systematic neuromonitoring – our treatment program for premature infants. Paediatria Croatica, 70(suppl 3), 198-202. https://doi.org/10.13112/pc.1206

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